Stereospecific effects of ketamine enantiomers on canine tracheal smooth muscle
نویسندگان
چکیده
منابع مشابه
Parasympathetic innervation of canine tracheal smooth muscle.
To investigate whether efferent parasympathetic fibers to the tracheal smooth muscle course through the pararecurrent nerve rather than the recurrent or the superior laryngeal nerve, we stimulated all three nerves in anesthetized dogs. We also recorded the pararecurrent nerve activity response to bronchoconstrictor stimuli and compared it with pressure changes inside a saline-filled cuff of an ...
متن کاملEffects of intravenous anesthetics on Ca2+ sensitivity in canine tracheal smooth muscle.
BACKGROUND Halothane and other volatile anesthetics relax airway smooth muscle in part by decreasing the amount of force produced for a particular intracellular calcium concentration (the Ca2+ sensitivity) during muscarinic receptor stimulation. In this study, ketamine, propofol, and midazolam were evaluated to determine whether the inhibitory effect of volatile anesthetics on this signal trans...
متن کاملEffects of Intravenous Anesthetics on Ca Sensitivity in Canine Tracheal Smooth Muscle
Background: Halothane and other volatile anesthetics relax airway smooth muscle in part by decreasing the amount of force produced for a particular intracellular calcium concentration (the Ca sensitivity) during muscarinic receptor stimulation. In this study, ketamine, propofol, and midazolam were evaluated to determine whether the inhibitory effect of volatile anesthetics on this signal transd...
متن کاملEffects of cromolyn and nedocromil on ion currents in canine tracheal smooth muscle.
Cromolyn and nedocromil are often used in the treatment of asthma. Recently, these agents have been shown to block Cl- currents and/or Ca2+ currents in a variety of cell preparations. Ca2+ and Cl- currents play central roles in excitation-contraction coupling in airway smooth muscle. This study therefore aimed to investigate the effects of these agents on membrane currents, elevations of [Ca2+]...
متن کاملEffects of anaesthetics on guineapig tracheal smooth muscle.
The effects of i.v. and local anaesthetics on guineapig tracheal smooth muscle have been investigated in vitro. Diazepam, propanidid and ketamine induced relaxation and antagonized histamine-, acetylcholine-and potassium chloride-induced contractures in the tracheal smooth muscle. The relaxing effects of the anaesthetics were not affected by propranolol. Thiopentone, at concentrations which wou...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1997
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0701280